Zenrelia

Zenrelia is a prescription veterinary medicine developed to relieve itching and inflammation in dogs suffering from allergic skin disorders, including atopic dermatitis.

What Is Zenrelia?

Zenrelia is a veterinary prescription medicine used to control itching and inflammation in dogs caused by allergic skin conditions such as atopic dermatitis. Available in the UK, this once-daily tablet helps improve comfort, sleep quality, and skin health without the need for steroids, providing a modern and effective solution for dogs prone to allergies.

Designed for long-term management of chronic allergies, Zenrelia for dogs targets the underlying itch-signal pathway to provide fast and lasting relief from scratching, redness and irritation.

FAQs

How does Zenrelia work?

Zenrelia contains ilunocitinib, a Janus kinase (JAK) inhibitor that blocks the action of cytokines (small proteins that trigger immune and inflammatory responses). By suppressing these overactive cytokines, Zenrelia interrupts the transmission of itch and inflammation signals, providing fast and sustained relief from allergic symptoms.

What’s the difference between Zenrelia and Apoquel?

When comparing Zenrelia vs Apoquel, both are JAK inhibitors that treat allergic itch, but they contain different active ingredients (ilunocitinib in Zenrelia and oclacitinib in Apoquel).

Zenrelia specifically targets a narrower range of JAK pathways (it predominantly blocks the JAK1-dependent cytokines, such as interleukins IL-31, IL-4, IL-13, and IL-6) that are directly responsible for triggering itch and inflammatory signalling in atopic dermatitis, which may result in fewer immune-related side effects in some dogs.

By contrast, oclacitinib in Apoquel exhibits broader JAK1 and partial JAK2 inhibitory activity, which effectively controls itch and inflammation, but can also influence a wider range of immune and haematopoietic functions. This means Zenrelia may offer a more focused mechanism of action, potentially resulting in fewer systemic immune-related side effects or long-term immunosuppressive risks.

Though both are highly effective for managing itching and inflammation.

How is Zenrelia for dogs given?

Your veterinarian determines Zenrelia dosing based on your dog’s body weight and the severity of its condition. It is typically administered once daily as an oral tablet and can be taken with or without food. Consistent dosing helps maintain stable therapeutic effects and prevent flare-ups.

Zenrelia doses available from Pet Drugs Online are:

How quickly does Zenrelia start working?

Clinical studies show that Zenrelia can significantly reduce itching within24 hours of administration. Continued daily use helps maintain long-term control of allergic dermatitis and improves skin barrier repair and coat condition.